Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The suppressive functions of Rora in B lineage cell proliferation and BCR/ABL1-induced B-ALL pathogenesis

1 Jan 2022

Abstract excerpt

RORA plays an important role in regulating circadian rhythms, inflammation, metabolism and cellular development. Herein, we explore the roles of Rora in B cell proliferation and differentiation, as well as in Ph + B-ALL. By using Rora loxp/loxp Mx-1-Cre mice, Rora was deleted in hematopoietic cells post Pipc induction. Rora deficiency mice were associated with an obvious accumulation of B cells in the peripheral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Acute Myeloid Leukemia Research
Share to Glutathione Transferases and Polymorphisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35414788
DOI: 10.7150/ijbs.68939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The suppressive functions of Rora in B lineage cell proliferation and BCR/ABL1-induced B-ALL pathogenesisPMID 35414788Read ↗

ROR1: an orphan becomes apparentSemantic proximity Read ↗

ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemiaSemantic proximity Read ↗

Rora Regulates Hematopoietic Stem Cell Phenotypes and Progression of Chronic Myelogenous Leukemia.Semantic proximity Read ↗

A comprehensive prognostic and immune analysis of LAPTM4B in pan-cancer and Philadelphia chromosome-positive acute lymphoblastic leukemiaSemantic proximity Read ↗

An instructive role for IL7RA in the development of human B-cell precursor leukemiaSemantic proximity Read ↗

The Onco-Embryonic Antigen ROR1 Is Expressed by a Variety of Human CancersSemantic proximity Read ↗

Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular MetabolismSemantic proximity Read ↗

Targeting ROR1 identifies new treatment strategies in hematological cancersSemantic proximity Read ↗

FCRL1 immunoregulation in B cell development and malignancySemantic proximity Read ↗

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signalingSemantic proximity Read ↗

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.