Article

Elucidating dynamics and regulation of alternative splicing in osteogenic differentiation

2020-10-30

Abstract excerpt

Nearly all human multi-exonic genes undergo alternative splicing (AS) via regulation by RNA-binding proteins (RBPs), but few studies have examined the temporal dynamics of AS and its regulation during cell differentiation in the bone niche. We sought to evaluate how AS, under the control of RBPs, affects cell fate commitment during induced osteogenic differentiation of human bone marrow-derived multipotent stem/st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4545754-7cfc-5aea-9978-654d8c58db5e
DOI: 10.1101/2020.10.30.362384

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Elucidating dynamics and regulation of alternative splicing in osteogenic differentiationDOI 10.1101/2020.10.30.362384Read

Exploration of Key Regulatory Factors for Continuous Regulation of Osteogenic Differentiation in Mesenchymal Stem Cells Based on Transcriptomic SequencingSemantic proximity Read

Exploration of Key Regulatory Factors in Mesenchymal Stem Cell Continuous Osteogenic Differentiation via Transcriptomic AnalysisSemantic proximity Read

Differential long noncoding RNA/mRNA expression profiling and functional network analysis during osteogenic differentiation of human bone marrow mesenchymal stem cellsSemantic proximity Read

ASTA-P: a pipeline for the detection, quantification and statistical analysis of complex alternative splicing eventsSemantic proximity Read

Single-Cell RNA-Sequencing Reveals the Skeletal Cellular Dynamics in Bone Repair and OsteoporosisSemantic proximity Read

Single-Cell Transcriptomic Sequencing Analyses of Cell Heterogeneity During Osteogenesis of Human Adipose-Derived Mesenchymal Stem CellsSemantic proximity Read

Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolutionSemantic proximity Read

Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesisSemantic proximity Read

Gene expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiationSemantic proximity Read

Combining single-cell transcriptomics and CellTagging to identify differentiation trajectories of human adipose-derived mesenchymal stem cellsSemantic proximity Read

A systematic dissection of human primary osteoblasts <i>in vivo</i> at single-cell resolutionSemantic proximity Read

Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cellsSemantic proximity Read