Article
Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2.
International journal of molecular sciences - 22 Mar 2022
Zvejniece Laura, Kozireva Svetlana, Rudevica Zanna, Leonciks Ainars, Ehlin-Henriksson Barbro, Kashuba Elena, Kholodnyuk Irina
Abstract excerpt
Chemokines and their receptors regulate the migration of immune cells and the dissemination of cancer cells. CCR1, CCR2, CCR3, and CCR5 all belong to a single protein homology cluster and respond to the same inflammatory chemokines. We previously reported that CCR1 and CCR2B are induced upon Epstein-Barr virus (EBV) infection of B cells in vitro. EBV is present in almost all cases of endemic Burkitt lymphoma...
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