Article
Defective Monocyte Enzymatic Function and an Inhibitory Immune Phenotype in Human Immunodeficiency Virus-Exposed Uninfected African Infants in the Era of Antiretroviral Therapy.
The Journal of infectious diseases - 28 Sept 2022
Afran Louise, Jambo Kondwani C, Nedi Wilfred, Miles David J C, Kiran Anmol, Banda Dominic H, Kamg'ona Ralph, Tembo Dumizulu, Pachnio Annette, Nastouli Eleni, Ferne Brigit, Mwandumba Henry C, Moss Paul, Goldblatt David, Rowland-Jones Sarah, Finn Adam, Heyderman Robert S
Abstract excerpt
BACKGROUND: Human immunodeficiency virus-exposed uninfected (HEU) infants are a rapidly expanding population in sub-Saharan Africa and are highly susceptible to encapsulated bacterial disease in the first year of life. The mechanism of this increased risk is still poorly understood. We investigated whether human immunodeficiency virus (HIV)-exposure dysregulates HEU immunity, vaccine-antibody production, and...
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