Article
CYP2D6 phenotype and ABCB1 haplotypes are associated with antipsychotic safety in adolescents experiencing acute psychotic episodes.
Drug metabolism and personalized therapy - 12 Aug 2021
Ivashchenko Dmitriy V, Yudelevich Daria A, Buromskaya Nina I, Shimanov Pavel V, Deitch Roman V, Akmalova Kristina A, Kachanova Anastasia A, Dorina Irina V, Nastovich Marina I, Grishina Elena A, Savchenko Lyudmila M, Shevchenko Yuriy S, Sychev Dmitriy A
Abstract excerpt
OBJECTIVES: To identify possible associations of CYP2D6, CYP3A4/5, and ABCB1 gene polymorphisms with the efficacy and safety of antipsychotics in adolescents with acute psychotic episodes. METHODS: We examined the associations of pharmacogenetic factors with the efficacy and safety of antipsychotics in 101 adolescents with acute psychotic episodes. The diagnosis on admission was "Brief psychotic disorder"...
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