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Article

Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery.

Neuron - 5 Oct 2006

Lee Virginia M-Y, Trojanowski John Q

Abstract excerpt

Classic Parkinson's disease (PD) is characterized by fibrillar alpha-synuclein inclusions known as Lewy bodies in the substantia nigra, which are associated with nigrostriatal degeneration. However, alpha-synuclein pathologies accumulate throughout the CNS in areas that also undergo progressive neurodegeneration, leading to dementia and other behavioral impairments in addition to parkinsonism. Although mutations...

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PMID: 17015225
DOI: 10.1016/j.neuron.2006.09.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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