Article
Pathogenic mechanisms of neurodegeneration in Parkinson disease.
Neurologic clinics - 1 Feb 2015
Mullin Stephen, Schapira Anthony H V
Abstract excerpt
The last 2 decades represent a period of unparalleled advancement in the understanding of the pathogenesis of Parkinson disease (PD). The discovery of several forms of familial parkinsonism with mendelian inheritance has elucidated insights into the mechanisms underlying the degeneration of dopaminergic neurons of the substantia nigra that histologically characterize PD. α-Synuclein, the principal component of...
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