RAS activation induces synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia.

doi:10.1038/s41375-022-01541-0

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Article

RAS activation induces synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia.

Leukemia - 1 May 2022

Decroocq Justine, Birsen Rudy, Montersino Camille, Chaskar Prasad, Mano Jordi, Poulain Laury, Friedrich Chloe, Alary Anne-Sophie, Guermouche Helene, Sahal Ambrine, Fouquet Guillemette, Gotanègre Mathilde, Simonetta Federico, Mouche Sarah, Gestraud Pierre, Lescure Auriane, Del Nery Elaine, Bosc Claudie, Grenier Adrien, Mazed Fetta, Mondesir Johanna, Chapuis Nicolas, Ho Liza, Boughalem Aicha, Lelorc'h Marc, Gobeaux Camille, Fontenay Michaela, Recher Christian, Vey Norbert, Guillé Arnaud, Birnbaum Daniel, Hermine Olivier, Radford-Weiss Isabelle, Tsantoulis Petros, Collette Yves, Castellano Rémy, Sarry Jean-Emmanuel, Pasmant Eric, Bouscary Didier, Kosmider Olivier, Tamburini Jerome

Abstract excerpt

Despite recent advances in acute myeloid leukemia (AML) molecular characterization and targeted therapies, a majority of AML cases still lack therapeutically actionable targets. In 127 AML cases with unmet therapeutic needs, as defined by the exclusion of ELN favorable cases and of FLT3-ITD mutations, we identified 51 (40%) cases with alterations in RAS pathway genes (RAS+, mostly NF1, NRAS, KRAS, and PTPN11...

Topics

Animals
Humans
Leukemia, Myeloid, Acute
Mice
Mitogen-Activated Protein Kinase Kinases
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidative Stress

Proto-Oncogene Proteins p21(ras)

Synthetic Lethal Mutations

fms-Like Tyrosine Kinase 3

Source

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Identifiers

PMID: 35354920
DOI: 10.1038/s41375-022-01541-0
PMCID: PMC9061298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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