Article
Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT).
Current medical research and opinion - 1 May 2018
Al-Amodi Amani M, Ghanem Neda Z, Aldakeel Sumayh A, Ibrahim Al Asoom Lubna, Rafique Ahmed Nazish, Almandil Noor B, Naserullah Zaki A, Al-Jarrash Sana, Shakil Akhtar Mohammed, AbdulAzeez Sayed, Al-Ali Amein K, Borgio J Francis
Abstract excerpt
INTRODUCTION: Detection of β-thalassemia trait or carriers (β-TT) depends significantly on an increase in Hemoglobin A2 (HbA2) levels, which is found at low levels (<3%) in normal healthy individuals and elevated levels (≥3.5%) in β-TT individuals. The study was designed to evaluate the reliability of the diagnostic parameter HbA2 in the differentiation of β-TT and non-β-TT in Saudis. METHODS: The widely used...
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