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MCT8 deficiency in Purkinje cells disrupts embryonic chicken cerebellar development

22 Nov 2016

Abstract excerpt

Inactivating mutations in the human SLC16A2 gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) result in the Allan-Herndon-Dudley syndrome accompanied by severe locomotor deficits. The underlying mechanisms of the associated cerebellar maldevelopment were studied using the chicken as a model. Electroporation of an MCT8-RNAi vector into the cerebellar anlage of a 3-day-old embryo...

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PMID: 27879339
DOI: 10.1530/joe-16-0323

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