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Article

Structure and Mutation of the Native Amine Dehydrogenase MATOUAmDH2.

Chembiochem : a European journal of chemical biology - 18 May 2022

Bennett Megan, Ducrot Laurine, Vergne-Vaxelaire Carine, Grogan Gideon

Abstract excerpt

Native amine dehydrogenases (nat-AmDHs) have recently emerged as a potentially valuable new reservoir of enzymes for the sustainable and selective synthesis of chiral amines, catalyzing the NAD(P)H-dependent ammoniation of carbonyl compounds with high activity and selectivity. MATOUAmDH2, recently identified from the Marine Atlas of Tara Oceans Unigenes (MATOUv1) database of eukaryotic genes, displays exceptional...

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PMID: 35349204
DOI: 10.1002/cbic.202200136
PMCID: PMC9325545

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