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Article

A reductive aminase from Aspergillus oryzae.

Nature chemistry - 1 Oct 2017

Aleku Godwin A, France Scott P, Man Henry, Mangas-Sanchez Juan, Montgomery Sarah L, Sharma Mahima, Leipold Friedemann, Hussain Shahed, Grogan Gideon, Turner Nicholas J

Abstract excerpt

Reductive amination is one of the most important methods for the synthesis of chiral amines. Here we report the discovery of an NADP(H)-dependent reductive aminase from Aspergillus oryzae (AspRedAm, Uniprot code Q2TW47) that can catalyse the reductive coupling of a broad set of carbonyl compounds with a variety of primary and secondary amines with up to >98% conversion and with up to >98% enantiomeric excess. In...

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PMID: 28937665
DOI: 10.1038/nchem.2782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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