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Article

Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1.

Cell - 4 Aug 2022

Li Linjie, Liao Hanyi, Meng Yumin, Li Weiwei, Han Pengcheng, Liu Kefang, Wang Qing, Li Dedong, Zhang Yanfang, Wang Liang, Fan Zheng, Zhang Yuqin, Wang Qiyue, Zhao Xin, Sun Yeping, Huang Niu, Qi Jianxun, Gao George Fu

Abstract excerpt

The currently circulating Omicron sub-variants are the SARS-CoV-2 strains with the highest number of known mutations. Herein, we found that human angiotensin-converting enzyme 2 (hACE2) binding affinity to the receptor-binding domains (RBDs) of the four early Omicron sub-variants (BA.1, BA.1.1, BA.2, and BA.3) follows the order BA.1.1 > BA.2 > BA.3 ≈ BA.1. The complex structures of hACE2 with RBDs of BA.1.1,...

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PMID: 35809570
DOI: 10.1016/j.cell.2022.06.023
PMCID: PMC9212699

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