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A Small-Plaque Isolate of the Zika Virus with Envelope Domain III Mutations Affect Viral Entry and Replication in Mammalian but Not Mosquito Cells.

Viruses - 26 Feb 2022

Jaimipuk Thitigun, Sachdev Saranya, Yoksan Sutee, Thepparit Chutima

Abstract excerpt

An Asian Zika virus (ZIKV) isolated from a Thai patient that was serially passaged in Primary Dog Kidney (PDK) cells for attenuation displayed both big and small plaque-forming viruses by the 7th passage. Two small-plaque isolates were selected and purified for characterization as attenuated ZIKV candidates. In vitro growth kinetics showed significantly reduced titers for small-plaque isolates in Vero cells early...

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PMID: 35336887
DOI: 10.3390/v14030480
PMCID: PMC8954177

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