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Article

Viewing Cortical Collecting Duct Function Through Phenotype-guided Single-Tubule Proteomics.

Function (Oxford, England) - 1 Jan 2020

Himmerkus Nina, Svendsen Samuel L, Quintanova Catarina, Bleich Markus, Von Schwerdtner Otto, Benzing Thomas, Welling Paul A, Leipziger Jens, Rinschen Markus M

Abstract excerpt

The revolution of the omics technologies has enabled profiling of the molecules of any sample. However, the heterogeneity of the kidney with highly specialized nephron segments like the cortical collecting duct (CCD) poses a challenge regarding integration of omics data and functional analysis. We examined function and proteome from the same single CCDs of C57Bl6 mice by investigating them in a double-barreled...

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Identifiers

PMID: 35330743
DOI: 10.1093/function/zqaa007
PMCID: PMC8788781

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