Article
Exosomal Carboxypeptidase E (CPE) and CPE-shRNA-Loaded Exosomes Regulate Metastatic Phenotype of Tumor Cells.
International journal of molecular sciences - 14 Mar 2022
Hareendran Sangeetha, Albraidy Bassam, Yang Xuyu, Liu Aiyi, Breggia Anne, Chen Clark C, Loh Y Peng
Abstract excerpt
BACKGROUND: Exosomes promote tumor growth and metastasis through intercellular communication, although the mechanism remains elusive. Carboxypeptidase E (CPE) supports the progression of different cancers, including hepatocellular carcinoma (HCC). Here, we investigated whether CPE is the bioactive cargo within exosomes, and whether it contributes to tumorigenesis, using HCC cell lines as a cancer model. METHODS:...
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