Article
The Influence of 5-HTTLPR, BDNF Rs6265 and COMT Rs4680 Polymorphisms on Impulsivity in Bipolar Disorder: The Role of Gender.
Genes - 9 Mar 2022
Boscutti Andrea, Pigoni Alessandro, Delvecchio Giuseppe, Lazzaretti Matteo, Mandolini Gian Mario, Girardi Paolo, Ferro Adele, Sala Michela, Abbiati Vera, Cappucciati Marco, Bellani Marcella, Perlini Cinzia, Rossetti Maria Gloria, Balestrieri Matteo, Damante Giuseppe, Bonivento Carolina, Rossi Roberta, Finos Livio, Serretti Alessandro, Brambilla Paolo, The Gecobip Group
Abstract excerpt
Impulsivity has been proposed as an endophenotype for bipolar disorder (BD); moreover, impulsivity levels have been shown to carry prognostic significance and to be quality-of-life predictors. To date, reports about the genetic determinants of impulsivity in mood disorders are limited, with no studies on BD individuals. Individuals with BD and healthy controls (HC) were recruited in the context of an...
Topics
- Bipolar Disorder
- Brain-Derived Neurotrophic Factor
- Catechol O-Methyltransferase
- Female
- Humans
- Impulsive Behavior
- Polymorphism, Single Nucleotide
- Serotonin Plasma Membrane Transport Proteins