Article
The Interplay between Transcriptional Factors and MicroRNAs as an Important Factor for Th17/Treg Balance in RA Patients.
International journal of molecular sciences - 28 Sept 2020
Kmiołek Tomasz, Rzeszotarska Ewa, Wajda Anna, Walczuk Ewa, Kuca-Warnawin Ewa, Romanowska-Próchnicka Katarzyna, Stypinska Barbara, Majewski Dominik, Jagodzinski Pawel Piotr, Pawlik Andrzej, Paradowska-Gorycka Agnieszka
Abstract excerpt
MicroRNAs regulate gene expression of transcriptional factors, which influence Th17/Treg (regulatory T cells) balance, establishing the molecular mechanism of genetic and epigenetic regulation of Treg and Th17 cells is crucial for understanding rheumatoid arthritis (RA) pathogenesis. The study goal was to understand the potential impact of the selected microRNAs expression profiles on Treg/Th17 cells frequency,...
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