Article
Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2005
Rodriguez Jorge A, Shaw Bryan Francis, Durazo Armando, Sohn Se Hui, Doucette Peter A, Nersissian Aram M, Faull Kym F, Eggers Daryl K, Tiwari Ashutosh, Hayward Lawrence J, Valentine Joan Selverstone
Abstract excerpt
The relative stabilities and structural properties of a representative set of 20 ALS-mutant Cu,Zn-superoxide dismutase apoproteins were examined by using differential scanning calorimetry and hydrogen-deuterium (H/D) exchange followed by MS. Contrary to recent reports from other laboratories, we found that ALS-mutant apoproteins are not universally destabilized by the disease-causing mutations. For example,...
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