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Thyroid hormone enhances stem cell maintenance and promotes lineage-specific differentiation in human embryonic stem cells

21 Mar 2022

Abstract excerpt

BACKGROUND: Thyroid hormone triiodothyronine (T3) is essential for embryogenesis and is commonly used during in vitro fertilization to ensure successful implantation. However, the regulatory mechanisms of T3 during early embryogenesis are largely unknown. METHOD: To study the impact of T3 on hPSCs, cell survival and growth were evaluated by measurement of cell growth curve, cloning efficiency, survival after...

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PMID: 35313973
DOI: 10.1186/s13287-022-02799-y

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