Sensory profiling in classical Ehlers-Danlos syndrome: a case-control study revealing pain characteristics, somatosensory changes, and impaired pain modulation

Abstract excerpt

Pain is one of the most important, yet poorly understood complaints in heritable connective tissue disorders (HCTD) caused by monogenic defects in extracellular matrix molecules. This is particularly the case for Ehlers-Danlos syndromes (EDS), paradigm collagen-related disorders. This study aimed to identify the pain signature and somatosensory characteristics in the rare classical type of EDS (cEDS) caused by def...

Topics

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• Collagen Type V
• Disease Models, Animal
• Ehlers-Danlos Syndrome
• Mice
• Mutation
• Pain
• Phenotype
• Skin

Identifiers and source

Literature Corpus work

a04fb533-b028-598a-8682-40390c4cfb02

DOI

10.1101/2023.02.24.23286404