Article
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Toxicology and applied pharmacology - 15 Apr 2022
Fu Nai-Jie, Xi Rui-Ying, Shi Xiao-Ke, Li Run-Ze, Zhang Zhong-Hui, Li Ling-Yu, Zhang Guo-Lin, Wang Fei
Abstract excerpt
Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations account for 35% of the genetic alterations in non-small cell lung cancer (NSCLC). The Src-homology region 2-containing protein tyrosine phosphatase 2 (SHP2), encoded by PTPN11, is closely involved in RAS downstream pathways and development of many tumors by affecting cell proliferation, differentiation, and immunity. Targeting SHP2 with small molecules...
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