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Article

Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).

Journal of medicinal chemistry - 25 Mar 2010

Zhang Xian, He Yantao, Liu Sijiu, Yu Zhihong, Jiang Zhong-Xing, Yang Zhenyun, Dong Yuanshu, Nabinger Sarah C, Wu Li, Gunawan Andrea M, Wang Lina, Chan Rebecca J, Zhang Zhong-Yin

Abstract excerpt

The Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) plays a pivotal role in growth factor and cytokine signaling. Gain-of-function SHP2 mutations are associated with Noonan syndrome, various kinds of leukemias, and solid tumors. Thus, there is considerable interest in SHP2...

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Identifiers

PMID: 20170098
DOI: 10.1021/jm901645u
PMCID: PMC2842125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20170098-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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