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Article

Correctors Rescue CFTR Mutations in Nucleotide-Binding Domain 1 (NBD1) by Modulating Proteostasis.

Chembiochem : a European journal of chemical biology - 15 Mar 2016

Lopes-Pacheco Miquéias, Sabirzhanova Inna, Rapino Daniele, Morales Marcelo M, Guggino William B, Cebotaru Liudmila

Abstract excerpt

We evaluated whether small molecule correctors could rescue four nucleotide-binding domain 1 (NBD1) mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (A455E, S492F, ΔI507, and R560T). We first transfected Cos-7 cells (green monkey kidney cells) with A455E, S492F, ΔI507, or R560T and created HEK-293 (human embryonic kidney cells) cell lines stably expressing these CFTR mutations. The...

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Identifiers

PMID: 26864378
DOI: 10.1002/cbic.201500620
PMCID: PMC5557405

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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