Article
Evaluation of a systems biology approach to identify pharmacological correctors of the mutant CFTR chloride channel.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jul 2016
Pesce Emanuela, Gorrieri Giulia, Sirci Francesco, Napolitano Francesco, Carrella Diego, Caci Emanuela, Tomati Valeria, Zegarra-Moran Olga, di Bernardo Diego, Galietta Luis J V
Abstract excerpt
BACKGROUND: Mistrafficking of CFTR protein caused by F508del, the most frequent mutation in cystic fibrosis (CF), can be corrected by cell incubation at low temperature, an effect that may be mediated by altered expression of proteostasis genes. METHODS: To identify small molecules mimicking low temperature, we compared gene expression profiles of cells kept at 27°C with those previously generated from more than...
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