Article
Driver Mutation Variant Allele Frequency in Circulating Tumor DNA and Association with Clinical Outcome in Patients with Non-Small Cell Lung Cancer and EGFR- and KRAS-Mutated Tumors.
The Journal of molecular diagnostics : JMD - 1 May 2022
Li Meijuan, Yang Lei, Hughes Jason, van den Hout Allison, Burns Christine, Woodhouse Ryan, Dennis Lucas, Hegde Priti, Oxnard Geoffery R, Vietz Christine
Abstract excerpt
Clinical implementation of mutational analysis for next-generation sequencing-based assays has largely been of a binary nature, with pathogenic mutations being reported as either positive or negative. Actionability on the continuous output of variant allele frequency (VAF) has not been well characterized in the clinical setting, thus limiting its use. In this study, analytical validity and performance of the...
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