Article
Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification.
European journal of medicinal chemistry - 15 Apr 2022
Carbone Daniela, Vestuto Vincenzo, Ferraro Maria Rosalia, Ciaglia Tania, Pecoraro Camilla, Sommella Eduardo, Cascioferro Stella, Salviati Emanuela, Novi Sara, Tecce Mario Felice, Amodio Giuseppina, Iraci Nunzio, Cirrincione Girolamo, Campiglia Pietro, Diana Patrizia, Bertamino Alessia, Parrino Barbara, Ostacolo Carmine
Abstract excerpt
The enzyme glutaminase-1 (GLS-1) has shown a clear and coherent implication in the progression and exacerbation of different aggressive tumors such as glioblastoma, hepatocarcinoma, pancreas, bone, and triple-negative breast cancer. Few chemotypes are currently available as selective GLS-1 inhibitors, and still, fewer of them are at the clinical stage. In the present paper, starting from a naturally-inspired...
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