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Article

Fbxo45-mediated NP-STEP46 degradation via K6-linked ubiquitination sustains ERK activity in lung cancer.

Molecular oncology - 1 Aug 2022

Wang Qian, Xu Ci, Cai Renjie, An Weishu, Yuan Haihua, Xu Ming

Abstract excerpt

Lung cancer is one of the most threatening malignant tumors to human health. Epidermal growth factor receptor (EGFR)-targeted therapy is a common and essential means for the clinical treatment of lung cancer. However, drug resistance has always affected the therapeutic effect and survival rate in non-small cell lung cancer (NSCLC). Tumor heterogeneity is a significant reason, yielding various drug resistance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35838331
DOI: 10.1002/1878-0261.13290
PMCID: PMC9394119

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