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Article

Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).

International journal of biological macromolecules - 15 May 2022

El-Shafai Nagi M, Masoud Mamdouh S, Ibrahim Mohamed M, Ramadan Mohamed S, Mersal Gaber A M, El-Mehasseb Ibrahim M

Abstract excerpt

The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF). The characterization process performs for confirming the formation of hybrid composite...

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Identifiers

PMID: 35278509
DOI: 10.1016/j.ijbiomac.2022.03.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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