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Article

The Acute Toxicity of Mineral Fibres: A Systematic In Vitro Study Using Different THP-1 Macrophage Phenotypes.

International journal of molecular sciences - 4 Mar 2022

Mirata Serena, Almonti Vanessa, Di Giuseppe Dario, Fornasini Laura, Raneri Simona, Vernazza Stefania, Bersani Danilo, Gualtieri Alessandro F, Bassi Anna Maria, Scarfì Sonia

Abstract excerpt

Alveolar macrophages are the first line of defence against detrimental inhaled stimuli. To date, no comparative data have been obtained on the inflammatory response induced by different carcinogenic mineral fibres in the three main macrophage phenotypes: M0 (non-activated), M1 (pro-inflammatory) and M2 (alternatively activated). To gain new insights into the different toxicity mechanisms of carcinogenic mineral...

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Identifiers

PMID: 35269982
DOI: 10.3390/ijms23052840
PMCID: PMC8911508

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