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Article

Structural, energetic and lipophilic analysis of SARS-CoV-2 non-structural protein 9 (NSP9).

Scientific reports - 26 Nov 2021

de O Araújo Jéssica, Pinheiro Silvana, Zamora William J, Alves Cláudio Nahum, Lameira Jerônimo, Lima Anderson H

Abstract excerpt

In SARS-CoV-2 replication complex, the Non-structural protein 9 (Nsp9) is an important RNA binding subunit in the RNA-synthesizing machinery. The dimeric forms of coronavirus Nsp9 increase their nucleic acid binding affinity and the N-finger motif appears to play a critical role in dimerization. Here, we present a structural, lipophilic and energetic study about the Nsp9 dimer of SARS-CoV-2 through computational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34837010
DOI: 10.1038/s41598-021-02366-0
PMCID: PMC8626507

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