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Article

Computational assay of H7N9 influenza neuraminidase reveals R292K mutation reduces drug binding affinity.

Scientific reports - 20 Dec 2013

Woods Christopher J, Malaisree Maturos, Long Ben, McIntosh-Smith Simon, Mulholland Adrian J

Abstract excerpt

The emergence of a novel H7N9 avian influenza that infects humans is a serious cause for concern. Of the genome sequences of H7N9 neuraminidase available, one contains a substitution of arginine to lysine at position 292, suggesting a potential for reduced drug binding efficacy. We have performed molecular dynamics simulations of oseltamivir, zanamivir and peramivir bound to H7N9, H7N9-R292K, and a structurally...

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Identifiers

PMID: 24356381
DOI: 10.1038/srep03561
PMCID: PMC3868970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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