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Article

Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application

1 Jan 2022

Abstract excerpt

Abstract BACKGROUND Oocyte activation deficiency (OAD) is attributed to the majority of cases underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte activation encompasses a series of concerted events, triggered by sperm-specific phospholipase C zeta (PLCζ), which elicits increases in free cytoplasmic calcium (Ca2+) in spatially and temporally specific oscillations. Defects...

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Identifiers

PMID: 35261925
DOI: 10.1093/hropen/hoac003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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