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Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

7 Mar 2022

Abstract excerpt

The extremophile Alvinella pompejana, an annelid worm living on the edge of hydrothermal vents in the Pacific Ocean, is an excellent model system for studying factors that govern protein stability. Low intrinsic stability is a crucial factor for the susceptibility of the transcription factor p53 to inactivating mutations in human cancer. Understanding its molecular basis may facilitate the design of novel...

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PMID: 35256607
DOI: 10.1038/s41419-022-04653-8

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