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Monocytic MDSCs homing to thymus contribute to age-related CD8+ T cell tolerance of HBV

7 Mar 2022

Abstract excerpt

Hepatitis B virus exposure in children usually develops into chronic hepatitis B (CHB). Although hepatitis B surface antigen (HBsAg)-specific CD8+ T cells contribute to resolve HBV infection, they are preferentially undetected in CHB patients. Moreover, the mechanism for this rarely detected HBsAg-specific CD8+ T cells remains unexplored. We herein found that the frequency of HBsAg-specific CD8+ T cells was...

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PMID: 35254403
DOI: 10.1084/jem.20211838

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