Article
In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression.
Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2012
Ramamoorthy Anuradha, Li Lang, Gaedigk Andrea, Bradford L DiAnne, Benson Eric A, Flockhart David A, Skaar Todd C
Abstract excerpt
Hepatic nuclear factor 4α (HNF4A) is a nuclear transcription factor that regulates the expression of many genes involved in drug disposition. To identify additional molecular mechanisms that regulate HNF4A, we identified microRNAs (miRNAs) that target HNF4A expression. In silico analyses suggested that HNF4A is targeted by many miRNAs. We conducted in vitro studies to validate several of these predictions. With...
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