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In-Depth Serum Proteomics by DIA-MS with <i>In Silico</i> Spectral Libraries Reveals Dynamics during the Active Phase of Systemic Juvenile Idiopathic Arthritis

15 Feb 2022

Abstract excerpt

In serum proteomics using mass spectrometry, the number of detectable proteins is reduced due to high-abundance proteins, such as albumin. However, recently developed data-independent acquisition mass spectrometry (DIA-MS) proteomics technology has made it possible to remarkably improve the number of proteins in a serum analysis by removing high-abundance proteins. Using this technology, we analyzed sera from...

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PMID: 35252692
DOI: 10.1021/acsomega.1c06681

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