Article
The relationship between the aggrecan VNTR polymorphism and its content in lumbar intervertebral discs.
Folia morphologica - 1 Jan 2023
Pękala P, Felkle D, Dykas K, Jarosz A, Elnazir P, Konopka T, Walocha J A, Dulinska-Litewka J
Abstract excerpt
BACKGROUND: There is a specific polymorphism of the ACAN gene called the variable number of tandem repeats (VNTR), which is particularly interesting in the light of the development of intervertebral disc pathology and associated low back pain. MATERIALS AND METHODS: The nucleus pulposus specimens were harvested from the L5/S1 intervertebral discs. The aggrecan content was determined using enzyme- linked...
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