Article
The sequence-structure-function relationship of intrinsic ERα disorder.
Nature - 1 Feb 2025
Du Zhanwen, Wang Han, Luo Shuqi, Yun Zixi, Wu Chen, Yang Wangfei, Buck Matthias, Zheng Wenwei, Hansen Alexandar L, Kao Hung-Ying, Yang Sichun
Abstract excerpt
The oestrogen receptor (ER or ERα), a nuclear hormone receptor that drives most breast cancer1, is commonly activated by phosphorylation at serine 118 within its intrinsically disordered N-terminal transactivation domain2,3. Although this modification enables oestrogen-independent ER function, its mechanism has remained unclear despite ongoing clinical trials of kinase inhibitors targeting this region4-6. By...
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