Article
The Interaction of NTN4 and miR-17-92 Polymorphisms on Breast Cancer Susceptibility in a Chinese Population.
Clinical breast cancer - 1 Jun 2022
Wang Yi-Shan, Guo Rong, Yang De-Chun, Xu Yi, Hui Ying-Xiang, Li Dan-Dan, Tang Shi-Cong, Tang Yi-Yin
Abstract excerpt
INTRODUCTION: Genome-wide association studies have identified a genetic variant rs17356907 in netrin 4 (NTN4) as a risk locus of breast cancer (BC) in Europeans. NTN4 is a target gene of miR-17-92 cluster that is an oncogenic miRNA in BC development. We aimed to replicate the rs17356907 in a Chinese population and examine the interaction of NTN4 and miR-17-92 on BC susceptibility. MATERIALS AND METHODS: The...
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