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Article

Understanding Gene-Lifestyle Interaction in Obesity: The Role of Mediation versus Moderation.

Lifestyle genomics - 1 Jan 2022

Pérusse Louis, Jacob Raphaëlle, Drapeau Vicky, Llewellyn Clare, Arsenault Benoit J, Bureau Alexandre, Labonté Marie-Ève, Tremblay Angelo, Vohl Marie-Claude

Abstract excerpt

BACKGROUND: Obesity results from complex interactions between genetic susceptibility to weight gain and poor eating and lifestyle behaviors. The approach that has been traditionally used in genetics to investigate gene-environment/lifestyle interaction in obesity is based on the concept of moderation or effect modification. Another approach called mediation analysis can be used to investigate gene-environment...

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PMID: 35231909
DOI: 10.1159/000523813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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