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Article

Mediators of the association between educational attainment and type 2 diabetes mellitus: a two-step multivariable Mendelian randomisation study.

Diabetologia - 1 Aug 2022

Zhang Jia, Chen Zekai, Pärna Katri, van Zon Sander K R, Snieder Harold, Thio Chris H L

Abstract excerpt

AIMS/HYPOTHESIS: Type 2 diabetes mellitus is a major health burden disproportionately affecting those with lower educational attainment (EA). We aimed to obtain causal estimates of the association between EA and type 2 diabetes and to quantify mediating effects of known modifiable risk factors. METHODS: We applied two-step, two-sample multivariable Mendelian randomisation (MR) techniques using SNPs as genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35482055
DOI: 10.1007/s00125-022-05705-6
PMCID: PMC9283137

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