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Detection of Circulating HPV16 DNA as a Biomarker for Cervical Cancer by a Bead-Based HPV Genotyping Assay.

Microbiology spectrum - 27 Apr 2022

Galati Luisa, Combes Jean-Damien, Le Calvez-Kelm Florence, McKay-Chopin Sandrine, Forey Nathalie, Ratel Mathis, McKay James, Waterboer Tim, Schroeder Lea, Clifford Gary, Tommasino Massimo, Gheit Tarik

Abstract excerpt

Human papillomavirus (HPV) circulating tumor DNA (HPV ctDNA) was proposed as a biomarker for the detection and disease monitoring of HPV-related cancers. One hundred eighty plasma samples obtained from women diagnosed with HPV16-positive cervical cancer (CC) (n = 100), HPV16-positive premalignant lesions (cervical intraepithelial neoplasia grade 3 [CIN3]) (n = 20), and HPV DNA-negative controls (n = 60) were...

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Identifiers

PMID: 35225653
DOI: 10.1128/spectrum.01480-21
PMCID: PMC9045285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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