Article
Detection, quantitation, and genotyping of human papillomavirus circulating tumor DNA by droplet digital PCR.
Journal of clinical microbiology - 10 Sept 2025
Fernholz Emily C, Routman David M, Van Abel Kathryn M, Moore Eric J, Ma Daniel J, Hunter Danielle E, Bartemes Kathleen R, Lewis James S, Wendlandt Erik B, Binnicker Matthew J
Abstract excerpt
Human papillomavirus (HPV) is comprised of >200 genotypes and has an ~8 kb, circular, double-stranded DNA genome. Transmission of HPV occurs through skin-to-skin contact and infection of squamous epithelial cells of cutaneous and mucosal surfaces. HPV genotypes are categorized as low- or high-risk (hrHPV) based on oncogenic potential. There are approximately 14 types of hrHPV that can cause several types of...
Topics
- Humans
- Polymerase Chain Reaction
- Papillomavirus Infections
- Circulating Tumor DNA
- Papillomaviridae
- Genotype
- Sensitivity and Specificity
- DNA, Viral
- Genotyping Techniques
- Male
- Female
- Human Papillomavirus Viruses