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Evaluation of hereditary/familial breast cancer patients with multigene targeted next generation sequencing panel and MLPA analysis in Turkey.

Cancer genetics - 1 Apr 2022

Bora Elcin, Caglayan Ahmet Okay, Koc Altug, Cankaya Tufan, Ozkalayci Hande, Kocabey Mehmet, Kemer Demet, Aksoy Suleyman, Alicikus Zumre Arican, Akin Isil Basara, Durak Merih Guray, Gurel Duygu, Yavuzsen Tugba, Sevinc Ali, Somali Isil, Gorken Ilknur, Balci Pinar, Karaoglu Aziz, Saydam Serdar, Ulgenalp Ayfer

Abstract excerpt

Breast cancer, a worldwide leading cause of cancer in women, may occur in familial cases. Germline mutations in BRCA1/2 genes are responsible for 15% of the familial cases. With the power of next generation sequencing (NGS) analysis, it is possible to analyze genes related to hereditary susceptibility to breast cancer and investigate the genetic etiology more thoroughly. In this study, we investigated 30 genes...

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PMID: 35220195
DOI: 10.1016/j.cancergen.2022.02.006

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