Article
Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction.
Diagnostic microbiology and infectious disease - 1 Apr 2022
Sartor Ivaine Tais Sauthier, Varela Fernanda Hammes, Meireles Mariana Rost, Kern Luciane Beatriz, Azevedo Thaís Raupp, Giannini Gabriela Luchiari Tumioto, da Silva Mariana Soares, Demoliner Meriane, Gularte Juliana Schons, de Almeida Paula Rodrigues, Fleck Juliane Deise, Zavaglia Gabriela Oliveira, Fernandes Ingrid Rodrigues, de David Caroline Nespolo, Santos Amanda Paz, de Almeida Walquiria Aparecida Ferreira, Porto Victor Bertollo Gomes, Scotta Marcelo Comerlato, Vieira Gustavo Fioravanti, Spilki Fernando Rosado, Stein Renato T, Polese-Bonatto Márcia
Abstract excerpt
We aimed to describe the SARS-CoV-2 lineages circulating early pandemic among samples with S gene dropout and characterize the receptor-binding domain (RBD) of viral spike protein. Adults and children older than 2 months with signs and symptoms of COVID-19 were prospectively enrolled from May to October in Porto Alegre, Brazil. All participants performed RT-PCR assay, and samples with S gene dropout and cycle...
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