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Mutational profile confers increased stability of SARS-CoV-2 spike protein in Brazilian isolates.

Journal of biomolecular structure & dynamics - 1 Jan 2022

Santos Felipe Rocha da Silva, de Azevedo Marcela Santiago Pacheco, Bielavsky Monica, da Costa Hernan Hermes Monteiro, Ribeiro Daniela Gomes, Nascimento Gleidson Guedes do, Marcondes Gabrielle Menezes Paz, de Castro Beatriz Portugal, de Lima Neto Daniel Ferreira, Prudencio Carlos Roberto

Abstract excerpt

Spike (S) protein has been recognized as a promising molecular target for diagnostic, vaccines and antiviral drugs development for COVID-19. In this study, we analyzed the most predominant mutations in the S protein of Brazilian isolates and predicted the effect of these amino acid alterations to protein conformation. A total of 25,924 sequences were obtained from GISAID for five regions of Brazilian territory...

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Brazil
COVID-19
Mutation
Protein Binding
SARS-CoV-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

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PMID: 34633892
DOI: 10.1080/07391102.2021.1982775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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