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Article

Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy.

International journal of molecular sciences - 18 Feb 2022

Morroni Jacopo, Schirone Leonardo, Valenti Valentina, Zwergel Clemens, Riera Carles Sánchez, Valente Sergio, Vecchio Daniele, Schiavon Sonia, Ragno Rino, Mai Antonello, Sciarretta Sebastiano, Lozanoska-Ochser Biliana, Bouchè Marina

Abstract excerpt

Chronic cardiac muscle inflammation and subsequent fibrotic tissue deposition are key features in Duchenne Muscular Dystrophy (DMD). The treatment of choice for delaying DMD progression both in skeletal and cardiac muscle are corticosteroids, supporting the notion that chronic inflammation in the heart plays a pivotal role in fibrosis deposition and subsequent cardiac dysfunction. Nevertheless, considering the...

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Identifiers

PMID: 35216371
DOI: 10.3390/ijms23042256
PMCID: PMC8880527

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