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Article

The Association of Cholesterol Uptake and Synthesis with Histology and Genotype in Cortisol-Producing Adenoma (CPA).

International journal of molecular sciences - 16 Feb 2022

Motomura Naoki, Yamazaki Yuto, Koga Daiki, Harashima Shogo, Gao Xin, Tezuka Yuta, Omata Kei, Ono Yoshikiyo, Morimoto Ryo, Satoh Fumitoshi, Nakamura Yasuhiro, Kwon Go Eun, Choi Man Ho, Ito Akihiro, Sasano Hironobu

Abstract excerpt

Cortisol-producing adenoma (CPA) is composed of clear and compact cells. Clear cells are lipid abundant, and compact ones lipid poor but associated with higher production of steroid hormones. PRKACA mutation (PRKACA mt) in CPA patients was reported to be associated with more pronounced clinical manifestation of Cushing's syndrome. In this study, we examined the association of histological features and genotypes...

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Identifiers

PMID: 35216289
DOI: 10.3390/ijms23042174
PMCID: PMC8875534

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