Article
Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation.
Differentiation; research in biological diversity - 1 Apr 2007
Battula Venkata Lokesh, Bareiss Petra M, Treml Sabrina, Conrad Sabine, Albert Ingrid, Hojak Sigrid, Abele Harald, Schewe Bernhard, Just Lothar, Skutella Thomas, Bühring Hans-Jörg
Abstract excerpt
Conventionally, mesenchymal stem cells (MSC) are generated by plating cells from bone marrow (BM) or other sources into culture flasks and selecting plastic-adherent cells with fibroblastoid morphology. These cells express CD9, CD10, CD13, CD73, CD105, CD166, and other markers but show only a weak or no expression of the embryonic markers stage-specific embryonic antigen-4 (SSEA-4), Oct-4 and nanog-3. Using a...
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